Axonal degeneration and neuroinflammation are increasingly recognised as pivotal processes in the pathogenesis of neurodegenerative diseases. Axonal degeneration refers to the progressive ...

A research team led by investigators at McMaster University has identified an axonal guidance signaling pathway that cancer cells use to infiltrate the brain. The combined results of preclinical in ...

A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University. The research also ...

A cross-sectional image of the mouse cerebral cortex in enlargement. The same method was applied as in the ferret. The cerebral cortex is shown in blue and some neurons are dyed green with GFP. In ...

BUFFALO, N.Y. — A hallmark of Parkinson’s disease is the buildup of Lewy bodies — misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere ...

Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that ...

A new study definitively reveals the existence of a system that had been theorized to clear metabolic wastes in the human brain. The study uses imaging in neurosurgery patients to show how brain's ...

Researchers have built an AI-powered model that traces how the brain’s electrical rhythms and physical wiring change together across nearly the entire human lifespan, from age 5 to age 100. The model, ...