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一文带你了解BTK抑制剂的十年变革:从血液肿瘤到自身免疫病的跨界 ...
BTK是一种由659个氨基酸组成的非受体酪氨酸激酶,分子量约76kDa,属于Tec激酶家族。其结构包含5个主要功能域,从N端到C端依次为: C端尾部:含核定位信号(NLS)和核输出信号(NES),调控BTK在胞质与细胞核间的穿梭,影响其功能多样性。 这些结构域通过协同 ...
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