The inefficiency induced by between-cluster variation in cluster randomized (CR) trials can be reduced by implementing a crossover (CO) design. In a simple CO trial, each subject receives each ...

Screening for prostate cancer continues to generate controversy because of concerns about over-diagnosis and unnecessary treatment. We describe the rationale, design and recruitment of the Cluster ...

Adjuvant Nivolumab in High-Risk Muscle-Invasive Urothelial Carcinoma: Expanded Efficacy From CheckMate 274 In this cluster-randomized clinical trial comparing 174,943 eligible residents in eight towns ...

Objectives: We assessed whether proactive care management for artificial intelligence (AI)–identified at-risk patients reduced preventable emergency department (ED) visits and hospital admissions (HAs ...