Microscopes have been fine-tuned to image cells in granular detail, with the most sophisticated instruments capable of resolving individual atoms within a protein. The expense of microscopes creates ...

A new microscopy method enables researchers to visualize the activity of the enzymes caspase-3 and alkaline phosphatase in various biological samples (Nat. Methods 2024, DOI: ...

Living organisms are complex systems with scales of organization spanning the range from Angstroms to meters. Even when consideration is limited to single cells and smaller, there is still a range of ...

A research team has established an optimized three-dimensional (3D) tissue-staining and observation technique based on existing tissue clearing technology. The study details how the new technique can ...

Sensing: point-of-care sensors, mobile-phone enabled sensors, field-based sensing and measurement systems with applications in mobile health and telemedicine, environmental monitoring (for example, ...

To ensure that the tissue structures of biological samples are easily recognisable under the electron microscope, they are treated with a staining agent. The standard staining agent for this is ...

Cryo-EM is referred to as a form of EM where a transmission electron microscope (TEM) is used to obtain the image of radiation-sensitive specimens under cryogenic conditions. The phrase cryo-EM is ...

For human researchers, it takes many years of work to discover new super-resolution microscopy techniques. The number of possible optical configurations of a microscope -- for example, where to place ...

Limited by the laws of physics, scientific discoveries and the advance of knowledge can be bound up in a series of slow proceedings. In microscopy, up until the early 21 st century, the diffraction ...