Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...

Nature makes amide bonds—the key linkages that string together amino acids in a polypeptide—like a knitting whiz. The ribosome in Escherichia coli bacteria, for example, can make eight amide bonds in ...

By understanding how milligram to kilogram peptide production is achieved safely, drug developers can better navigate the ...

Chemists created a gold-catalyzed method to make non-natural amino acids ready for peptide synthesis, expanding drug design options beyond 22 natural types. (Nanowerk News) Ozempic has been making ...

Cyclic peptides offer enhanced stability and bioavailability, but precise cyclization strategies and specialized synthetic techniques are required to maintain their biological activity. A recent ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish.

The breakthrough could simplify the production of complex proteins used in cancer immunotherapy and other advanced medicines ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...