Background: Preimplantation genetic testing for aneuploidy (PGT-A) and structural rearrangement (PGT-SR) have been widely used within indications of previous miscarriages, repeated implantation ...

In an agricultural advancement, scientists have deciphered the genetic underpinnings of watermelon chromosomal translocations, the key to cultivating fruits with fewer seeds. The global demand for ...

Herein, we investigate the genomic landscape of 632 TASs, spanning the most common histotypes: Ewing sarcoma (ES, n = 196), desmoplastic small round cell sarcoma (DSRCT, n = 115), solitary fibrous ...

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

Robertsonian translocation is the most common form of chromosomal translocation in humans. It means that two chromosomes, the structures that make up a person’s DNA, join together in an abnormal way.

Abnormalities in the structure of chromosomes within someone’s genetic makeup are called structural chromosomal abnormalities. Robertsonian translocations are very rare structural chromosomal ...