NAT10-mediated mRNA acetylation links neural activity to local protein synthesis at synapses, influencing memory consolidation.

A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of Copenhagen demonstrate that a simple addition to mRNA vaccines can significantly ...

Genome-wide CRISPR knockout screens to identify cellular regulators of LNP-based mRNA vaccines. mRNAs encoding Green Fluorescent Protein (GFP) were in vitro transcribed (IVT) and delivered to knockout ...

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

N4-Acetylation of cytidine (ac4C) is an mRNA modification that enhances cellular mRNA stability and translation. Most eukaryotic organisms catalyze ac4C using a homologue of human N-acetyltransferase ...

Researchers have redesigned lipid nanoparticles to make mRNA vaccine delivery more precise, reducing off-target effects.

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to ...

Advanced analytics and artificial intelligence (AI) will help make mRNA vaccines and therapeutics better by allowing biopharma engineers to fine-tune the enzymes used to manufacture such products.